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Research library / TB-500

TB-500 research

3 verified publications on file. Each one was read back from PubMed before it was listed, and each states the experimental model it used.

2Preclinical
0Clinical
1Reviews
2026-08-29Last verified
What this page is: a citation list, not a claim. Every study on file for TB-500 is preclinical or a review of preclinical work. None of it describes an effect in people. We publish the model on every entry because that is the detail marketing copy drops first.

Every paper below studies thymosin beta-4, the full-length 43-amino-acid protein. Much of what is sold as 'TB-500' is the shorter LKKTETQ fragment, which is a different molecule. Research on the protein is not automatically research on the contents of the vial - confirm from the COA which one a product contains.

Regulatory status: TB-500 is not an FDA-approved drug; the FDA lists 'Thymosin beta-4, fragment (LKKTETQ), also known as TB-500' among bulk drug substances that may present significant safety risks (Category 2) for compounding, page content current as of 04/22/2026.

Preclinical studies

2

  1. Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

    Thymosin beta4 accelerates wound healing

    J Invest Dermatol. 1999;113(3):364-8. doi:10.1046/j.1523-1747.1999.00708.x · PMID 10469335

    ModelRat full-thickness wound model, plus keratinocyte migration assays (Boyden chamber)

  2. Philp D, Goldstein AL, Kleinman HK

    Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development

    Mech Ageing Dev. 2004;125(2):113-5. doi:10.1016/j.mad.2003.11.005 · PMID 15037013

    ModelNormal and aged rodents

Review study

1

  1. Dube KN, Smart N

    Thymosin beta-4 and the vasculature: multiple roles in development, repair and protection against disease

    Expert Opin Biol Ther. 2018;18(sup1):131-9. doi:10.1080/14712598.2018.1459558 · PMID 30063849

    ModelNarrative review of developmental, repair and vascular-protection literature

Looking at this for yourself? These are laboratory studies. Whether any compound is right for a person is a medical question we cannot answer — talk to a licensed clinician. Everything here is for research use only, and no health, dosing, or usage claim is made anywhere on this page.
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Citations are transcribed from the publisher record on PubMed and re-checked when a compound page is updated. Found an error or a study we should add? Tell us — corrections are published, not quietly patched.